High severity · published Sep 27, 2026
CVE-2026-100845
MONAI before 1.6.0 Remote Code Execution via NumpyReader
7.8
CVSS
0.2%
EPSS
No
On KEV
Description
MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.
CVSS vector
CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H
Attack vector
Local
Complexity
Low
Privileges
None
User interaction
Required
Confidentiality
High
Integrity
High
Availability
High
Scope
Unchanged
Exploitation
Is it being used?
Exploit prediction (EPSS)0.2% · higher than 10% of CVEs
Exploited in the wildNo evidence yet
CISA KEVNot listed
Ransomware campaign useNot known
Affected products
Which versions
MO
MONAI · Project-MONAI
before 1.6.0 · source: vendor, NVD
References
NVD
https://nvd.nist.gov/vuln/detail/CVE-2026-100845
CVE.org
https://www.cve.org/CVERecord?id=CVE-2026-100845
vendor-advisory
https://github.com/Project-MONAI/MONAI/security/advisories/GHSA-wg9g-w2j2-8pgr
third-party-advisory
https://www.vulncheck.com/advisories/monai-before-1.6.0-remote-code-execution-via-numpyreader
More from MONAI
8.8
CVE-2026-118683
MONAI 1.2.0 before 1.6.1 Code Execution via bundle configs/logging.conf
8.8
CVE-2026-100846
MONAI before 1.5.2 Remote Code Execution via Pickle Deserialization
8.8
CVE-2026-100842
MONAI through 1.6.0 _get_fake_spatial_shape eval() Sandbox Bypass via Attribute Chains
8.8
CVE-2025-58757
MONAI's unsafe use of Pickle deserialization may lead to RCE
8.8
CVE-2025-58756
MONAI's unsafe torch usage may lead to arbitrary code execution